Metabolic effects of furaldehydes and impacts on biotechnological processes.

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Metabolic effects of furaldehydes and impacts on biotechnological processes. / Almeida, Joao; Wiman, Magnus; Gorwa-Grauslund, Marie-Francoise; Gorsich, Steven; Lidén, Gunnar.

In: Applied Microbiology and Biotechnology, Vol. 82, No. 4, 2009, p. 625-638.

Research output: Contribution to journalReview article

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TY - JOUR

T1 - Metabolic effects of furaldehydes and impacts on biotechnological processes.

AU - Almeida, Joao

AU - Wiman, Magnus

AU - Gorwa-Grauslund, Marie-Francoise

AU - Gorsich, Steven

AU - Lidén, Gunnar

PY - 2009

Y1 - 2009

N2 - There is a growing awareness that lignocellulose will be a major raw material for production of both fuel and chemicals in the coming decades-most likely through various fermentation routes. Considerable attention has been given to the problem of finding efficient means of separating the major constituents in lignocellulose (i.e., lignin, hemicellulose, and cellulose) and to efficiently hydrolyze the carbohydrate parts into sugars. In these processes, by-products will inevitably form to some extent, and these will have to be dealt with in the ensuing microbial processes. One group of compounds in this category is the furaldehydes. 2-Furaldehyde (furfural) and substituted 2-furaldehydes-most importantly 5-hydroxymethyl-2-furaldehyde-are the dominant inhibitory compounds found in lignocellulosic hydrolyzates. The furaldehydes are known to have biological effects and act as inhibitors in fermentation processes. The effects of these compounds will therefore have to be considered in the design of biotechnological processes using lignocellulose. In this short review, we take a look at known metabolic effects, as well as strategies to overcome problems in biotechnological applications caused by furaldehydes.

AB - There is a growing awareness that lignocellulose will be a major raw material for production of both fuel and chemicals in the coming decades-most likely through various fermentation routes. Considerable attention has been given to the problem of finding efficient means of separating the major constituents in lignocellulose (i.e., lignin, hemicellulose, and cellulose) and to efficiently hydrolyze the carbohydrate parts into sugars. In these processes, by-products will inevitably form to some extent, and these will have to be dealt with in the ensuing microbial processes. One group of compounds in this category is the furaldehydes. 2-Furaldehyde (furfural) and substituted 2-furaldehydes-most importantly 5-hydroxymethyl-2-furaldehyde-are the dominant inhibitory compounds found in lignocellulosic hydrolyzates. The furaldehydes are known to have biological effects and act as inhibitors in fermentation processes. The effects of these compounds will therefore have to be considered in the design of biotechnological processes using lignocellulose. In this short review, we take a look at known metabolic effects, as well as strategies to overcome problems in biotechnological applications caused by furaldehydes.

U2 - 10.1007/s00253-009-1875-1

DO - 10.1007/s00253-009-1875-1

M3 - Review article

VL - 82

SP - 625

EP - 638

JO - European Journal of Applied Microbiology and Biotechnology

T2 - European Journal of Applied Microbiology and Biotechnology

JF - European Journal of Applied Microbiology and Biotechnology

SN - 1432-0614

IS - 4

ER -