Metabolic factors and blood cancers among 578,000 adults in the metabolic syndrome and cancer project (Me-Can)

Research output: Contribution to journalArticle


title = "Metabolic factors and blood cancers among 578,000 adults in the metabolic syndrome and cancer project (Me-Can)",
abstract = "We investigated associations between metabolic factors and blood cancer subtypes. Data on body mass index (BMI), blood pressure, blood glucose, total cholesterol, and triglycerides from seven prospective cohorts were pooled (n = 578,700; mean age = 44 years). Relative risks of blood cancers were calculated from Cox regression models. During mean follow-up of 12 years, 2,751 incident and 1,070 fatal cases of blood cancers occurred. Overall, higher BMI was associated with an increased blood cancer risk. In gender-specific subgroup analyses, BMI was positively associated with blood cancer risk (p = 0.002), lymphoid neoplasms (p = 0.01), and Hodgkin's lymphoma (p = 0.02) in women. Further associations with BMI were found for high-grade B-cell lymphoma (p = 0.02) and chronic lymphatic leukemia in men (p = 0.05) and women (p = 0.01). Higher cholesterol levels were inversely associated with myeloid neoplasms in women (p = 0.01), particularly acute myeloid leukemia (p = 0.003), and glucose was positively associated with chronic myeloid leukemia in women (p = 0.03). In men, glucose was positively associated with risk of high-grade B-cell lymphoma and multiple myeloma, while cholesterol was inversely associated with low-grade B-cell lymphoma. The metabolic syndrome score was related to 48 {\%} increased risk of Hodgkin's lymphoma among women. BMI showed up as the most consistent risk factor, particularly in women. A clear pattern was not found for other metabolic factors.",
keywords = "Cancer, Biomarker, Epidemiology, Leukemia, Lymphoma",
author = "Gabriele Nagel and Tanja Stocks and Daniela Spaeth and Anette Hjartaker and Bjorn Lindkvist and Goran Hallmans and Hakan Jonsson and Tone Bjorge and Jonas Manjer and Christel Haggstrom and Anders Engeland and Hanno Ulmer and Randi Selmer and Hans Concin and Paer Stattin and Schlenk, {Richard F.}",
year = "2012",
doi = "10.1007/s00277-012-1489-z",
language = "English",
volume = "91",
pages = "1519--1531",
journal = "Hematology and Cell Therapy",
issn = "1432-0584",
publisher = "Springer",
number = "10",