Metabolic factors and blood cancers among 578,000 adults in the metabolic syndrome and cancer project (Me-Can)

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Metabolic factors and blood cancers among 578,000 adults in the metabolic syndrome and cancer project (Me-Can). / Nagel, Gabriele; Stocks, Tanja; Spaeth, Daniela; Hjartaker, Anette; Lindkvist, Bjorn; Hallmans, Goran; Jonsson, Hakan; Bjorge, Tone; Manjer, Jonas; Haggstrom, Christel; Engeland, Anders; Ulmer, Hanno; Selmer, Randi; Concin, Hans; Stattin, Paer; Schlenk, Richard F.

In: Annals of Hematology, Vol. 91, No. 10, 2012, p. 1519-1531.

Research output: Contribution to journalArticle

Harvard

Nagel, G, Stocks, T, Spaeth, D, Hjartaker, A, Lindkvist, B, Hallmans, G, Jonsson, H, Bjorge, T, Manjer, J, Haggstrom, C, Engeland, A, Ulmer, H, Selmer, R, Concin, H, Stattin, P & Schlenk, RF 2012, 'Metabolic factors and blood cancers among 578,000 adults in the metabolic syndrome and cancer project (Me-Can)', Annals of Hematology, vol. 91, no. 10, pp. 1519-1531. https://doi.org/10.1007/s00277-012-1489-z

APA

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Nagel G, Stocks T, Spaeth D, Hjartaker A, Lindkvist B, Hallmans G, Jonsson H, Bjorge T, Manjer J, Haggstrom C, Engeland A, Ulmer H, Selmer R, Concin H, Stattin P, Schlenk RF. 2012. Metabolic factors and blood cancers among 578,000 adults in the metabolic syndrome and cancer project (Me-Can). Annals of Hematology. 91(10):1519-1531. https://doi.org/10.1007/s00277-012-1489-z

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Nagel, Gabriele ; Stocks, Tanja ; Spaeth, Daniela ; Hjartaker, Anette ; Lindkvist, Bjorn ; Hallmans, Goran ; Jonsson, Hakan ; Bjorge, Tone ; Manjer, Jonas ; Haggstrom, Christel ; Engeland, Anders ; Ulmer, Hanno ; Selmer, Randi ; Concin, Hans ; Stattin, Paer ; Schlenk, Richard F. / Metabolic factors and blood cancers among 578,000 adults in the metabolic syndrome and cancer project (Me-Can). In: Annals of Hematology. 2012 ; Vol. 91, No. 10. pp. 1519-1531.

RIS

TY - JOUR

T1 - Metabolic factors and blood cancers among 578,000 adults in the metabolic syndrome and cancer project (Me-Can)

AU - Nagel, Gabriele

AU - Stocks, Tanja

AU - Spaeth, Daniela

AU - Hjartaker, Anette

AU - Lindkvist, Bjorn

AU - Hallmans, Goran

AU - Jonsson, Hakan

AU - Bjorge, Tone

AU - Manjer, Jonas

AU - Haggstrom, Christel

AU - Engeland, Anders

AU - Ulmer, Hanno

AU - Selmer, Randi

AU - Concin, Hans

AU - Stattin, Paer

AU - Schlenk, Richard F.

PY - 2012

Y1 - 2012

N2 - We investigated associations between metabolic factors and blood cancer subtypes. Data on body mass index (BMI), blood pressure, blood glucose, total cholesterol, and triglycerides from seven prospective cohorts were pooled (n = 578,700; mean age = 44 years). Relative risks of blood cancers were calculated from Cox regression models. During mean follow-up of 12 years, 2,751 incident and 1,070 fatal cases of blood cancers occurred. Overall, higher BMI was associated with an increased blood cancer risk. In gender-specific subgroup analyses, BMI was positively associated with blood cancer risk (p = 0.002), lymphoid neoplasms (p = 0.01), and Hodgkin's lymphoma (p = 0.02) in women. Further associations with BMI were found for high-grade B-cell lymphoma (p = 0.02) and chronic lymphatic leukemia in men (p = 0.05) and women (p = 0.01). Higher cholesterol levels were inversely associated with myeloid neoplasms in women (p = 0.01), particularly acute myeloid leukemia (p = 0.003), and glucose was positively associated with chronic myeloid leukemia in women (p = 0.03). In men, glucose was positively associated with risk of high-grade B-cell lymphoma and multiple myeloma, while cholesterol was inversely associated with low-grade B-cell lymphoma. The metabolic syndrome score was related to 48 % increased risk of Hodgkin's lymphoma among women. BMI showed up as the most consistent risk factor, particularly in women. A clear pattern was not found for other metabolic factors.

AB - We investigated associations between metabolic factors and blood cancer subtypes. Data on body mass index (BMI), blood pressure, blood glucose, total cholesterol, and triglycerides from seven prospective cohorts were pooled (n = 578,700; mean age = 44 years). Relative risks of blood cancers were calculated from Cox regression models. During mean follow-up of 12 years, 2,751 incident and 1,070 fatal cases of blood cancers occurred. Overall, higher BMI was associated with an increased blood cancer risk. In gender-specific subgroup analyses, BMI was positively associated with blood cancer risk (p = 0.002), lymphoid neoplasms (p = 0.01), and Hodgkin's lymphoma (p = 0.02) in women. Further associations with BMI were found for high-grade B-cell lymphoma (p = 0.02) and chronic lymphatic leukemia in men (p = 0.05) and women (p = 0.01). Higher cholesterol levels were inversely associated with myeloid neoplasms in women (p = 0.01), particularly acute myeloid leukemia (p = 0.003), and glucose was positively associated with chronic myeloid leukemia in women (p = 0.03). In men, glucose was positively associated with risk of high-grade B-cell lymphoma and multiple myeloma, while cholesterol was inversely associated with low-grade B-cell lymphoma. The metabolic syndrome score was related to 48 % increased risk of Hodgkin's lymphoma among women. BMI showed up as the most consistent risk factor, particularly in women. A clear pattern was not found for other metabolic factors.

KW - Cancer

KW - Biomarker

KW - Epidemiology

KW - Leukemia

KW - Lymphoma

U2 - 10.1007/s00277-012-1489-z

DO - 10.1007/s00277-012-1489-z

M3 - Article

VL - 91

SP - 1519

EP - 1531

JO - Hematology and Cell Therapy

T2 - Hematology and Cell Therapy

JF - Hematology and Cell Therapy

SN - 1432-0584

IS - 10

ER -