Metabolic risk factors and cervical cancer in the metabolic syndrome and cancer project (Me-Can)

Research output: Contribution to journalArticle

Abstract

Background. Little is known about the association between metabolic risk factors and cervical cancer carcinogenesis. Material and methods. During mean follow-up of 11 years of the Me-Can cohort (N = 288,834) 425 invasive cervical cancer cases were diagnosed. Hazard ratios (HRs) were estimated by the use of Cox proportional hazards regression models for quintiles and standardized z-scores (with a mean of 0 and a SD of 1) of BMI, blood pressure, glucose, cholesterol, triglycerides and MetS score. Risk estimates were corrected for random error in the measurements. Results. BMI (per 1SD increment) was associated with 12%, increase of cervical cancer risk, blood pressure with 25% and triglycerides with 39%, respectively. In models including all metabolic factors, the associations for blood pressure and triglycerides persisted. The metabolic syndrome (MetS) score was associated with 26% increased corrected risk of cervical cancer. Triglycerides were stronger associated with squamous cell carcinoma (HR 1.48; 95% CI, 1.20-1.83) than with adenocarcinoma (0.92, 0.54-1.56). Among older women cholesterol (50-70 years 1.34; 1.00-1.81), triglycerides (50-70 years 1.49, 1.03-2.16 and >= 70 years 1.54, 1.09-2.19) and glucose (>= 70 years 1.87, 1.13-3.11) were associated with increased cervical cancer risk. Conclusion. The presence of obesity, elevated blood pressure and triglycerides were associated with increased risk of cervical cancer. (C) 2012 Elsevier Inc. All rights reserved.

Details

Authors
  • Hanno Ulmer
  • Tone Bjorge
  • Hans Concin
  • Annekatrin Lukanova
  • Jonas Manjer
  • Goran Hallmans
  • Wegene Borena
  • Christel Haggstrom
  • Anders Engeland
  • Martin Almquist
  • Hakan Jonsson
  • Randi Selmer
  • Par Stattin
  • Steinar Tretli
  • Andrea Kleiner
  • Tanja Stocks
  • Gabriele Nagel
Organisations
External organisations
  • Umeå University
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Surgery

Keywords

  • Metabolic factors, Cervical cancer, Epidemiology, CONOR
Original languageEnglish
Pages (from-to)330-335
JournalGynecologic Oncology
Volume125
Issue number2
Publication statusPublished - 2012
Publication categoryResearch
Peer-reviewedYes