Metabolite-related dietary patterns and the development of islet autoimmunity

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title = "Metabolite-related dietary patterns and the development of islet autoimmunity",
abstract = "The role of diet in type 1 diabetes development is poorly understood. Metabolites, which reflect dietary response, may help elucidate this role. We explored metabolomics and lipidomics differences between 352 cases of islet autoimmunity (IA) and controls in the TEDDY (The Environmental Determinants of Diabetes in the Young) study. We created dietary patterns reflecting pre-IA metabolite differences between groups and examined their association with IA. Secondary outcomes included IA cases positive for multiple autoantibodies (mAb+). The association of 853 plasma metabolites with outcomes was tested at seroconversion to IA, just prior to seroconversion, and during infancy. Key compounds in enriched metabolite sets were used to create dietary patterns reflecting metabolite composition, which were then tested for association with outcomes in the nested case-control subset and the full TEDDY cohort. Unsaturated phosphatidylcholines, sphingomyelins, phosphatidylethanolamines, glucosylceramides, and phospholipid ethers in infancy were inversely associated with mAb+ risk, while dicarboxylic acids were associated with an increased risk. An infancy dietary pattern representing higher levels of unsaturated phosphatidylcholines and phospholipid ethers, and lower sphingomyelins was protective for mAb+ in the nested case-control study only. Characterization of this high-risk infant metabolomics profile may help shape the future of early diagnosis or prevention efforts. {\textcopyright} 2019, The Author(s).",
author = "Johnson, {Randi K.} and {\AA}ke Lernmark and {Andr{\'e}n Aronsson}, Carin and Maria Ask and Jenny Bremer and Corrado Cilio and Emelie Ericson-Hallstr{\"o}m and {Bj{\"o}rne Fors}, Annika and Lina Fransson and Thomas Gard and Rasmus Bennet and Monica Hansen and Suzanne Hyberg-Karlsson and Hanna Jisser and Fredrik Johansen and Berglind J{\'o}nsd{\'o}ttir and SILVIJA JOVIC and {Elding Larsson}, Helena and Marielle Lindstr{\"o}m and Markus Lundgren and {M{\aa}nsson Martinez}, Maria and Maria Markan and Melin, {Marie Jessica} and Zeliha Mestan and Nilsson, {Caroline N} and Karin Ottosson and Kobra Rahmati and Anita Ramelius and Falastin Salami and Anette Sj{\"o}berg and Birgitta Sj{\"o}berg and Carina T{\"o}rn and Anne Wallin and {\AA}sa Wimar and Sofie {\AA}berg and Norris, {Jill M} and {TEDDY Study Group}",
note = "Export Date: 28 October 2019",
year = "2019",
doi = "10.1038/s41598-019-51251-4",
language = "English",
volume = "9",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",