Metabolite-related dietary patterns and the development of islet autoimmunity

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Metabolite-related dietary patterns and the development of islet autoimmunity. / Johnson, Randi K. ; Lernmark, Åke; Andrén Aronsson, Carin; Ask, Maria; Bremer, Jenny; Cilio, Corrado; Ericson-Hallström, Emelie; Björne Fors, Annika; Fransson, Lina; Gard, Thomas; Bennet, Rasmus; Hansen, Monica; Hyberg-Karlsson, Suzanne; Jisser, Hanna; Johansen, Fredrik; Jónsdóttir, Berglind; JOVIC, SILVIJA; Elding Larsson, Helena; Lindström, Marielle; Lundgren, Markus; Månsson Martinez, Maria; Markan, Maria; Melin, Marie Jessica; Mestan, Zeliha; Nilsson, Caroline N; Ottosson, Karin; Rahmati, Kobra; Ramelius, Anita; Salami, Falastin; Sjöberg, Anette; Sjöberg, Birgitta; Törn, Carina; Wallin, Anne; Wimar, Åsa; Åberg, Sofie; Norris, Jill M; TEDDY Study Group.

In: Scientific Reports, Vol. 9, No. 1, 14819, 2019.

Research output: Contribution to journalArticle

Harvard

Johnson, RK, Lernmark, Å, Andrén Aronsson, C, Ask, M, Bremer, J, Cilio, C, Ericson-Hallström, E, Björne Fors, A, Fransson, L, Gard, T, Bennet, R, Hansen, M, Hyberg-Karlsson, S, Jisser, H, Johansen, F, Jónsdóttir, B, JOVIC, SILVIJA, Elding Larsson, H, Lindström, M, Lundgren, M, Månsson Martinez, M, Markan, M, Melin, MJ, Mestan, Z, Nilsson, CN, Ottosson, K, Rahmati, K, Ramelius, A, Salami, F, Sjöberg, A, Sjöberg, B, Törn, C, Wallin, A, Wimar, Å, Åberg, S, Norris, JM & TEDDY Study Group 2019, 'Metabolite-related dietary patterns and the development of islet autoimmunity', Scientific Reports, vol. 9, no. 1, 14819. https://doi.org/10.1038/s41598-019-51251-4

APA

Johnson, R. K., Lernmark, Å., Andrén Aronsson, C., Ask, M., Bremer, J., Cilio, C., Ericson-Hallström, E., Björne Fors, A., Fransson, L., Gard, T., Bennet, R., Hansen, M., Hyberg-Karlsson, S., Jisser, H., Johansen, F., Jónsdóttir, B., JOVIC, SILVIJA., Elding Larsson, H., Lindström, M., ... TEDDY Study Group (2019). Metabolite-related dietary patterns and the development of islet autoimmunity. Scientific Reports, 9(1), [14819]. https://doi.org/10.1038/s41598-019-51251-4

CBE

Johnson RK, Lernmark Å, Andrén Aronsson C, Ask M, Bremer J, Cilio C, Ericson-Hallström E, Björne Fors A, Fransson L, Gard T, Bennet R, Hansen M, Hyberg-Karlsson S, Jisser H, Johansen F, Jónsdóttir B, JOVIC SILVIJA, Elding Larsson H, Lindström M, Lundgren M, Månsson Martinez M, Markan M, Melin MJ, Mestan Z, Nilsson CN, Ottosson K, Rahmati K, Ramelius A, Salami F, Sjöberg A, Sjöberg B, Törn C, Wallin A, Wimar Å, Åberg S, Norris JM, TEDDY Study Group. 2019. Metabolite-related dietary patterns and the development of islet autoimmunity. Scientific Reports. 9(1):Article 14819. https://doi.org/10.1038/s41598-019-51251-4

MLA

Vancouver

Author

Johnson, Randi K. ; Lernmark, Åke ; Andrén Aronsson, Carin ; Ask, Maria ; Bremer, Jenny ; Cilio, Corrado ; Ericson-Hallström, Emelie ; Björne Fors, Annika ; Fransson, Lina ; Gard, Thomas ; Bennet, Rasmus ; Hansen, Monica ; Hyberg-Karlsson, Suzanne ; Jisser, Hanna ; Johansen, Fredrik ; Jónsdóttir, Berglind ; JOVIC, SILVIJA ; Elding Larsson, Helena ; Lindström, Marielle ; Lundgren, Markus ; Månsson Martinez, Maria ; Markan, Maria ; Melin, Marie Jessica ; Mestan, Zeliha ; Nilsson, Caroline N ; Ottosson, Karin ; Rahmati, Kobra ; Ramelius, Anita ; Salami, Falastin ; Sjöberg, Anette ; Sjöberg, Birgitta ; Törn, Carina ; Wallin, Anne ; Wimar, Åsa ; Åberg, Sofie ; Norris, Jill M ; TEDDY Study Group. / Metabolite-related dietary patterns and the development of islet autoimmunity. In: Scientific Reports. 2019 ; Vol. 9, No. 1.

RIS

TY - JOUR

T1 - Metabolite-related dietary patterns and the development of islet autoimmunity

AU - Johnson, Randi K.

AU - Lernmark, Åke

AU - Andrén Aronsson, Carin

AU - Ask, Maria

AU - Bremer, Jenny

AU - Cilio, Corrado

AU - Ericson-Hallström, Emelie

AU - Björne Fors, Annika

AU - Fransson, Lina

AU - Gard, Thomas

AU - Bennet, Rasmus

AU - Hansen, Monica

AU - Hyberg-Karlsson, Suzanne

AU - Jisser, Hanna

AU - Johansen, Fredrik

AU - Jónsdóttir, Berglind

AU - JOVIC, SILVIJA

AU - Elding Larsson, Helena

AU - Lindström, Marielle

AU - Lundgren, Markus

AU - Månsson Martinez, Maria

AU - Markan, Maria

AU - Melin, Marie Jessica

AU - Mestan, Zeliha

AU - Nilsson, Caroline N

AU - Ottosson, Karin

AU - Rahmati, Kobra

AU - Ramelius, Anita

AU - Salami, Falastin

AU - Sjöberg, Anette

AU - Sjöberg, Birgitta

AU - Törn, Carina

AU - Wallin, Anne

AU - Wimar, Åsa

AU - Åberg, Sofie

AU - Norris, Jill M

AU - TEDDY Study Group

N1 - Export Date: 28 October 2019

PY - 2019

Y1 - 2019

N2 - The role of diet in type 1 diabetes development is poorly understood. Metabolites, which reflect dietary response, may help elucidate this role. We explored metabolomics and lipidomics differences between 352 cases of islet autoimmunity (IA) and controls in the TEDDY (The Environmental Determinants of Diabetes in the Young) study. We created dietary patterns reflecting pre-IA metabolite differences between groups and examined their association with IA. Secondary outcomes included IA cases positive for multiple autoantibodies (mAb+). The association of 853 plasma metabolites with outcomes was tested at seroconversion to IA, just prior to seroconversion, and during infancy. Key compounds in enriched metabolite sets were used to create dietary patterns reflecting metabolite composition, which were then tested for association with outcomes in the nested case-control subset and the full TEDDY cohort. Unsaturated phosphatidylcholines, sphingomyelins, phosphatidylethanolamines, glucosylceramides, and phospholipid ethers in infancy were inversely associated with mAb+ risk, while dicarboxylic acids were associated with an increased risk. An infancy dietary pattern representing higher levels of unsaturated phosphatidylcholines and phospholipid ethers, and lower sphingomyelins was protective for mAb+ in the nested case-control study only. Characterization of this high-risk infant metabolomics profile may help shape the future of early diagnosis or prevention efforts. © 2019, The Author(s).

AB - The role of diet in type 1 diabetes development is poorly understood. Metabolites, which reflect dietary response, may help elucidate this role. We explored metabolomics and lipidomics differences between 352 cases of islet autoimmunity (IA) and controls in the TEDDY (The Environmental Determinants of Diabetes in the Young) study. We created dietary patterns reflecting pre-IA metabolite differences between groups and examined their association with IA. Secondary outcomes included IA cases positive for multiple autoantibodies (mAb+). The association of 853 plasma metabolites with outcomes was tested at seroconversion to IA, just prior to seroconversion, and during infancy. Key compounds in enriched metabolite sets were used to create dietary patterns reflecting metabolite composition, which were then tested for association with outcomes in the nested case-control subset and the full TEDDY cohort. Unsaturated phosphatidylcholines, sphingomyelins, phosphatidylethanolamines, glucosylceramides, and phospholipid ethers in infancy were inversely associated with mAb+ risk, while dicarboxylic acids were associated with an increased risk. An infancy dietary pattern representing higher levels of unsaturated phosphatidylcholines and phospholipid ethers, and lower sphingomyelins was protective for mAb+ in the nested case-control study only. Characterization of this high-risk infant metabolomics profile may help shape the future of early diagnosis or prevention efforts. © 2019, The Author(s).

U2 - 10.1038/s41598-019-51251-4

DO - 10.1038/s41598-019-51251-4

M3 - Article

C2 - 31616039

VL - 9

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 14819

ER -