Metalloantibiotic Mn(II)-bacitracin complex mimicking manganese superoxide dismutase

Research output: Contribution to journalArticle

Abstract

Superoxide dismutase (SOD) activities of various metallobacitracin complexes were evaluated using the riboflavin-methionine-nitro blue tetrazolium assay. The radical scavenging activity of various metallobacitracin complexes was shown to be higher than those of the negative controls, e.g., free transition metal ions and metal-free bacitracin. The SOD activity of the complex was found to be in the order of Mn(II) > Cu(II) > Co(II) > Ni(II). Furthermore, the effect of bacitracin and their complexation to metals on various microorganisms was assessed by antibiotic susceptibility testing. Moreover, molecular modeling and quantum chemical calculation of the metallobacitracin complex was performed to evaluate the correlation of electrostatic charge of transition metal ions on the SOD activity. (c) 2006 Elsevier Inc. All rights reserved.

Details

Authors
  • Theeraphon Piacham
  • C Isarankura-Na-Ayuldhya
  • C Nantasenamat
  • S Yainoy
  • Lei Ye
  • Leif Bülow
  • V Prachayasittikul
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Biological Sciences

Keywords

  • molecular, modeling, SOD mimic, SOD, superoxide dismutase, antibiotic, bacitracin
Original languageEnglish
Pages (from-to)925-930
JournalBiochemical and Biophysical Research Communications
Volume341
Issue number4
Publication statusPublished - 2006
Publication categoryResearch
Peer-reviewedYes