Method for the biological monitoring of hexahydrophthalic anhydride by the determination of hexahydrophthalic acid in urine using gas chromatography and selected-ion monitoring

Research output: Contribution to journalArticle

Bibtex

@article{fa172fcbdec841889a6f7864c79ddbff,
title = "Method for the biological monitoring of hexahydrophthalic anhydride by the determination of hexahydrophthalic acid in urine using gas chromatography and selected-ion monitoring",
abstract = "A method for the determination of hexahydrophthalic acid, a metabolite of hexahydrophthalic anhydride, in human urine has been developed. The urine was worked-up by liquid-solid extraction, esterified with boron trifluoride-methanol, and analysed by capillary gas chromatography and selected-ion monitoring. Hexadeuterium-labelled hexahydrophthalic acid was used as the internal standard. The precision was 4% at 0.7 microgram/ml and 5% at 0.07 microgram/ml. The recovery of the acid for the overall method was 101% at 0.07 micrograms/ml of urine (with a coefficient of variation of 4%) and 95% at 0.7 microgram/ml (coefficient of variation 2%). The limit of detection was 20 ng/ml urine.",
author = "J{\"o}nsson, {Bo A} and Gunnar Skarping",
year = "1991",
language = "English",
volume = "572",
pages = "117--131",
journal = "Journal of chromatography. A",
issn = "0021-9673",
publisher = "Elsevier",
number = "1-2",

}