Methylated RASSF1A in malignant peripheral nerve sheath tumors identifies neurofibromatosis type 1 patients with inferior prognosis.

Research output: Contribution to journalArticle

Abstract

Malignant peripheral nerve sheath tumor (MPNST) is a rare and highly aggressive disease with no evidence of effect from adjuvant therapy. It is further associated with the hereditary syndrome neurofibromatosis type 1 (NF1). Silencing of the tumor suppressor gene RASSF1A through DNA promoter hypermethylation is known to be involved in cancer development, but its impact in MPNSTs remains unsettled.

Details

Authors
  • Stine A Danielsen
  • Guro E Lind
  • Matthias Kolberg
  • Maren Høland
  • Bodil Bjerkehagen
  • Kirsten Sundby Hall
  • Eva van den Berg
  • Fredrik Mertens
  • Sigbjørn Smeland
  • Piero Picci
  • Ragnhild A Lothe
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Medical Genetics
Original languageEnglish
Pages (from-to)63-69
JournalNeuro-Oncology
Volume17
Issue number1
Publication statusPublished - 2015
Publication categoryResearch
Peer-reviewedYes

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