Mevalonate inhibits acid sphingomyelinase activity, increases sphingomyelin levels and inhibits cell proliferation of HepG2 and Caco-2 cells.

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Abstract

Sphingomyelin (SM) and cholesterol are two types of lipid closely related biophysically. Treating the cells with exogenous sphingomyelinase (SMase) induces trafficking of cholesterol from membrane to intracellular pools and inhibition of cholesterol synthesis. In the present work, we address a question whether increased cholesterol synthesis affects hydrolysis of SM by endogenous SMases.

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  • Cell and Molecular Biology
Original languageEnglish
Article number130
JournalLipids in Health and Disease
Volume14
Publication statusPublished - 2015
Publication categoryResearch
Peer-reviewedYes

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