Mevalonate inhibits acid sphingomyelinase activity, increases sphingomyelin levels and inhibits cell proliferation of HepG2 and Caco-2 cells.

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Bibtex

@article{50e414b54877494f9ce949b44b430981,
title = "Mevalonate inhibits acid sphingomyelinase activity, increases sphingomyelin levels and inhibits cell proliferation of HepG2 and Caco-2 cells.",
abstract = "Sphingomyelin (SM) and cholesterol are two types of lipid closely related biophysically. Treating the cells with exogenous sphingomyelinase (SMase) induces trafficking of cholesterol from membrane to intracellular pools and inhibition of cholesterol synthesis. In the present work, we address a question whether increased cholesterol synthesis affects hydrolysis of SM by endogenous SMases.",
author = "Ying Chen and Shu-Chang Xu and Rui-Dong Duan",
year = "2015",
doi = "10.1186/s12944-015-0137-8",
language = "English",
volume = "14",
journal = "Lipids in Health and Disease",
issn = "1476-511X",
publisher = "BioMed Central (BMC)",

}