Microbial Translocation Correlates with the Severity of Both HIV-1 and HIV-2 Infections

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Abstract

Microbial translocation has been linked to systemic immune activation during human immunodeficiency virus (HIV) type 1 infection. Here, we show that an elevated level of microbial translocation, measured as plasma lipopolysaccharide (LPS) concentration, correlates with AIDS in both individuals infected with HIV type 1 and individuals infected with HIV type 2. LPS concentration also correlates with CD4(+) T cell count and viral load independently of HIV type. Furthermore, elevated plasma LPS concentration was found to be concomitant with defective innate and mitogen responsiveness. We suggest that microbial translocation may contribute to loss of CD4(+) T cells, increase in viral load, and defective immune stimuli responsiveness during both HIV type 1 and HIV type 2 infections.

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Subject classification (UKÄ) – MANDATORY

  • Infectious Medicine
Original languageEnglish
Pages (from-to)1150-1154
JournalJournal of Infectious Diseases
Volume201
Issue number8
Publication statusPublished - 2010
Publication categoryResearch
Peer-reviewedYes
Event5th Smögen Symposium on Virology - Smögen, Sweden
Duration: 2009 Aug 202009 Aug 22

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Division of Medical Microbiology (013250400), Infectious Diseases Research Unit (013242010), Division of Infection Medicine (SUS) (013008000)