MicroRNA-124 Is a Subventricular Zone Neuronal Fate Determinant.

Research output: Contribution to journalArticle

Abstract

New neurons are continuously generated from neural stem cells with astrocyte properties, which reside in close proximity to the ventricle in the postnatal and adult brain. In this study we found that microRNA-124 (miR-124) dictates postnatal neurogenesis in the mouse subventricular zone. Using a transgenic reporter mouse we show that miR-124 expression is initiated in the rapid amplifying progenitors and remains expressed in the resulting neurons. When we stably inhibited miR-124 in vivo, neurogenesis was blocked, leading to the appearance of ectopic cells with astrocyte characteristics in the olfactory bulb. Conversely, when we overexpressed miR-124, neural stem cells were not maintained in the subventricular zone and neurogenesis was lost. In summary, our results demonstrate that miR-124 is a neuronal fate determinant in the subventricular zone.

Details

Authors
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurosciences
Original languageEnglish
Pages (from-to)8879-8889
JournalThe Journal of neuroscience : the official journal of the Society for Neuroscience
Volume32
Issue number26
Publication statusPublished - 2012
Publication categoryResearch
Peer-reviewedYes

Total downloads

No data available

Related research output

Malin Åkerblom, 2014, Molecular Neurogenetics, Faculty of Medicine, Lund University. 137 p.

Research output: ThesisDoctoral Thesis (compilation)

Sachdeva, R., 2013, Molecular Neurogenetics, Faculty of Medicine, Lund University. 96 p.

Research output: ThesisDoctoral Thesis (compilation)

View all (2)