Midlife risk factor exposure and incidence of cardiac arrest depending on cardiac or non-cardiac origin

Research output: Contribution to journalArticle

Abstract

Objective: Little is known about midlife risk factors of future cardiac arrest. Our objective was to evaluate cardiovascular risk factors in midlife in relation to the risk of cardiac arrest (CA) of cardiac and non-cardiac origin later in life. Methods: We cross-matched individuals of the population based Malmö Diet and Cancer study (n = 30,447) with the local CA registry of the city of Malmö. Baseline exposures were related to incident CA. Results: During a mean follow-up of 17.6. ±. 4.6. years, 378 CA occurred, of whom 17.2% survived to discharge. Independent midlife risk factors for CA of cardiac origin included coronary artery disease (HR 2.84 (1.86-4.34) (p <. 0.001)), diabetes mellitus (HR 2.37 (1.61-3.51) (p <. 0.001)) and smoking (HR 1.95 (1.49-2.55) (p <. 0.001)). Dyslipidemia and history of stroke were also significantly associated with an elevated risk for CA of cardiac origin.Independent midlife risk factors for CA of non-cardiac origin included obesity (BMI>30kg/m2) (HR 2.37 (1.51-3.71) (p <0.001)), smoking (HR 2.05 (1.33-3.15) (p <0.001)) and being on antihypertensive treatment (HR 2.25 (1.46-3.46) (p <0.001)). Conclusion: Apart from smoking, which increases the risk of CA in general, the midlife risk factor pattern differs between CA of cardiac and non-cardiac origin. Whereas CA of cardiac origin is predicted by history of cardiovascular disease, dyslipidemia and diabetes mellitus, the main risk factors for CA of non-cardiac origin are obesity and hypertension. In addition to control of classical cardiovascular risk factors for prevention of CA, our results suggest that prevention of midlife obesity may reduce the risk of CA of non-cardiac origin.

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Authors
Organisations
External organisations
  • Skåne University Hospital
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cardiac and Cardiovascular Systems
Original languageEnglish
Pages (from-to)398-402
JournalInternational Journal of Cardiology
Volume240
Early online date2016 Oct 3
Publication statusPublished - 2017
Publication categoryResearch
Peer-reviewedYes

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