Minimizing tissue-material interaction in microsensor for subcutaneous glucose monitoring

Research output: Contribution to journalArticle


A new implantable electrocatalytic glucose sensor for subcutaneous glucose monitoring has been fabricated by immobilizing glucose oxidase on a chemically modified carbon fiber. The sensor was inserted subcutaneously on a male spraguely rat without any incision after dipping the microsensor in the rat's serum for 3 days. The so called "stained" microsensor, operated in the amperometric mode with an applied potential of +0.23 V versus Ag vertical bar AgCl, was able to directly measure the glucose concentration upon infusion of glucose. The results obtained were encouraging, with the response time was less than 2 s and the apparent Michaelis-Menten value at 5.1 +/- 0.5 mM. The "stained" microsensor shows good stability and reproducibility with constant response spanned over 25 days. Most common interferences in glucose analysis were minimized by the outerlayer Nafion((R)). Hematology examinations showed minimal material-tissue interaction. Use of such mechanical devices will allow a more refined understanding towards glucose control in diabetic patients as the implanted microsensor was not effected by biocompatibility failures. (c) 2006 Elsevier B.V. All rights reserved.


  • Farook Ahmad
  • Andreas Christenson
  • Martina Bainbridge
  • Ahmad Pauzi Mohd Yusof
  • Sulaiman Ab Ghani
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Analytical Chemistry


  • biocompatibility, hematology, subcutaneous, microsensor, rat's serum
Original languageEnglish
Pages (from-to)1625-1632
JournalBiosensors & Bioelectronics
Issue number8
Publication statusPublished - 2007
Publication categoryResearch

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Analytical Chemistry (S/LTH) (011001004)