Minor components with smooth muscle relaxing properties from scented myrrh (Commiphora guidotti)

Research output: Contribution to journalArticle

Abstract

All sesquiterpenes present in a sample of scented myrrh were isolated and characterised. Seven compounds, with cadinane, guaiane, oplopane, and eudesmane skeletons, were obtained, of which two are new and two are reported from a natural source for the first time. The major component, T-cadinol, has previously been shown to possess smooth muscle-relaxing properties, and the major purpose of the investigation was to compare the effects of the minor and more polar sesquiterpenes with that of T-cadinol in the rat aorta. Like T-cadinol, the minor sesquiterpenes are more efficient in reducing K(+)-induced contractions than those induced by the alpha-adrenoceptor agonist phenylephrine, however, they were all less potent than T-cadinol.

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Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Medicinal Chemistry
  • Dermatology and Venereal Diseases
  • Pharmacology and Toxicology

Keywords

  • Scented myrrh, Commiphora guidotti, Burseraceae, sesquiterpenes, T-cadinol, smooth muscle relaxant
Original languageEnglish
Pages (from-to)251-254
JournalPlanta Medica
Volume63
Issue number3
Publication statusPublished - 1997
Publication categoryResearch
Peer-reviewedYes

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Department of Dermatology and Venereology (Lund) (013006000), Division of Clinical Chemistry and Pharmacology (013250300), Organic chemistry (S/LTH) (011001240)