Minor components with smooth muscle relaxing properties from scented myrrh (Commiphora guidotti)

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Minor components with smooth muscle relaxing properties from scented myrrh (Commiphora guidotti). / Andersson, Maria; Bergendorff, Ola; Shan, Rudong; Zygmunt, Peter; Sterner, Olov.

In: Planta Medica, Vol. 63, No. 3, 1997, p. 251-254.

Research output: Contribution to journalArticle

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TY - JOUR

T1 - Minor components with smooth muscle relaxing properties from scented myrrh (Commiphora guidotti)

AU - Andersson, Maria

AU - Bergendorff, Ola

AU - Shan, Rudong

AU - Zygmunt, Peter

AU - Sterner, Olov

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Department of Dermatology and Venereology (Lund) (013006000), Division of Clinical Chemistry and Pharmacology (013250300), Organic chemistry (S/LTH) (011001240)

PY - 1997

Y1 - 1997

N2 - All sesquiterpenes present in a sample of scented myrrh were isolated and characterised. Seven compounds, with cadinane, guaiane, oplopane, and eudesmane skeletons, were obtained, of which two are new and two are reported from a natural source for the first time. The major component, T-cadinol, has previously been shown to possess smooth muscle-relaxing properties, and the major purpose of the investigation was to compare the effects of the minor and more polar sesquiterpenes with that of T-cadinol in the rat aorta. Like T-cadinol, the minor sesquiterpenes are more efficient in reducing K(+)-induced contractions than those induced by the alpha-adrenoceptor agonist phenylephrine, however, they were all less potent than T-cadinol.

AB - All sesquiterpenes present in a sample of scented myrrh were isolated and characterised. Seven compounds, with cadinane, guaiane, oplopane, and eudesmane skeletons, were obtained, of which two are new and two are reported from a natural source for the first time. The major component, T-cadinol, has previously been shown to possess smooth muscle-relaxing properties, and the major purpose of the investigation was to compare the effects of the minor and more polar sesquiterpenes with that of T-cadinol in the rat aorta. Like T-cadinol, the minor sesquiterpenes are more efficient in reducing K(+)-induced contractions than those induced by the alpha-adrenoceptor agonist phenylephrine, however, they were all less potent than T-cadinol.

KW - Scented myrrh

KW - Commiphora guidotti

KW - Burseraceae

KW - sesquiterpenes

KW - T-cadinol

KW - smooth muscle relaxant

U2 - 10.1055/s-2006-957665

DO - 10.1055/s-2006-957665

M3 - Article

VL - 63

SP - 251

EP - 254

JO - Planta Medica

T2 - Planta Medica

JF - Planta Medica

SN - 0032-0943

IS - 3

ER -