Mitochondria and the Brain: Bioenergetics and Beyond

Research output: Contribution to journalArticle

Abstract

The view of mitochondria acting solely as a powerhouse of the cell is no longer accurate. Besides cell bioenergetics, primary targets of mitochondrial studies include their interplay with essential processes within the cell, including redox and calcium homeostasis, and apoptosis. Recent studies evidence the dynamic behavior of mitochondria, continuously moving, fusing, and dividing, and the interaction of these events with cellular degeneration and plasticity in neural cells. Our review summarizes novel data and technologies that are developed and applied to the identification and clarification of the mitochondrial role in neural plasticity using both cultured cells and in vivo approaches. The complete understanding and modulation of such mechanisms may represent a novel and promising therapeutic approach for treatment of diseases affecting central and peripheral nervous system.

Details

Authors
Organisations
External organisations
  • University of Toulouse
  • Pontifical Catholic University of Rio Grande do Sul
  • Federal University of Rio de Janeiro
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurosciences

Keywords

  • Brain metabolism, Mitochondria, MRS, Neurogenesis
Original languageEnglish
Pages (from-to)219-238
JournalNeurotoxicity Research
Volume36
Issue number2
Early online date2019 Jun 1
Publication statusPublished - 2019
Publication categoryResearch
Peer-reviewedYes