Mitochondrial Potentiation Ameliorates Age-Related Heterogeneity in Hematopoietic Stem Cell Function

Research output: Contribution to journalArticle

Abstract

HSC aging is clinically associated with risk of anemia, immune compromise, and malignancy. Mansell et al. show that mitochondrial activity is directly linked to age-related performance of HSCs and that its perturbation has direct consequences for HSC function, resulting in alleviation or prevention of hematopoietic aging.

Details

Authors
Organisations
External organisations
  • University College London
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cell and Molecular Biology

Keywords

  • Aging, Hematopoietc Stem Cell, Lineage bias, Mitochondria, Mitochondrial Membrane Potential, Mitoquinol, Transcription Rate
Original languageEnglish
Pages (from-to)241-256.e6
JournalCell Stem Cell
Volume28
Issue number2
Early online date2020 Oct 20
Publication statusPublished - 2021
Publication categoryResearch
Peer-reviewedYes

Bibliographic note

© 2020 The Authors. Published by Elsevier Inc.