MLL/GAS7 fusion in a pediatric case of t(11;17)(q23;p13)-positive precursor B-cell acute lymphoblastic leukemia

Research output: Contribution to journalLetter

Abstract

AML/GAS7, resulting from t(11;17)(q23;p13), has been reported in one case of treatment-related acute myeloid leukemia (AML). We present a de novo case of t(11;17)-positive pediatric acute lymphoblastic leukemia. Fluorescent in situ hybridization and reverse transcriptase polymerase chain reaction analyses revealed an MLL/GAS7 chimera identical to the one previously described in AML. The molecular genetic features of MLL/GAS7 and the clinical impact of t(11;17) are discussed.

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Authors
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Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Hematology

Keywords

  • GAS7, MLL, ALL, translocation, fusion
Original languageEnglish
Pages (from-to)1287-1288
JournalHaematologica
Volume91
Issue number9
Publication statusPublished - 2006
Publication categoryResearch
Peer-reviewedNo