Modeling and Estimation of Temporal Episode Patterns in Paroxysmal Atrial Fibrillation

Research output: Contribution to journalArticle

Abstract

Objective: The present study proposes a model-based, statistical approach to characterizing episode patterns in paroxysmal atrial fibrillation (AF). Thanks to the rapid advancement of noninvasive monitoring technology, the proposed approach should become increasingly relevant in clinical practice. Methods: History-dependent point process modeling is employed to characterize AF episode patterns, using a novel alternating, bivariate Hawkes self-exciting model. In addition, a modified version of a recently proposed statistical model to simulate AF progression throughout a lifetime is considered, involving non-Markovian rhythm switching and survival functions. For each model, the maximum likelihood estimator is derived and used to find the model parameters from observed data. Results: Using three databases with a total of 59 long-term ECG recordings, the goodness-of-fit analysis demonstrates that the proposed alternating, bivariate Hawkes model fits SR-to-AF transitions in 40 recordings and AF-to-SR transitions in 51; the corresponding numbers for the AF model with non-Markovian rhythm switching are 40 and 11, respectively. Moreover, the results indicate that the model parameters related to AF episode clustering, i.e., aggregation of temporal AF episodes, provide information complementary to the well-known clinical parameter AF burden. Conclusion: Point process modeling provides a detailed characterization of the occurrence pattern of AF episodes that may improve the understanding of arrhythmia progression.

Details

Authors
Organisations
External organisations
  • Kaunas University of Technology
  • Aalborg University
  • Saint Petersburg State University
  • Skåne University Hospital
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cardiac and Cardiovascular Systems
  • Medical Biotechnology

Keywords

  • alternating bivariate Hawkes model, Atrial fibrillation, episode clustering, maximum likelihood estimation, point process modeling
Original languageEnglish
Article number9097442
Pages (from-to)319-329
Number of pages11
JournalIEEE Transactions on Biomedical Engineering
Volume68
Issue number1
Publication statusPublished - 2021
Publication categoryResearch
Peer-reviewedYes