Modelling human rostro-caudal neural patterning with a microfluidic morphogenic gradient

Research output: Chapter in Book/Report/Conference proceedingPaper in conference proceeding

Abstract

The study of biological mechanisms involved in human fetal brain development requires suitable models. To date, most findings have been acquired from animal models that fail to account for human-specific developmental traits. To counteract this limitation, a novel in vitro model is proposed where human pluripotent stem cells are differentiated into a coherent fetal brain tissue in a gradient forming microfluidic system. Stainings show that the model can be used to investigate the patterning, an important developmental event, of stem cells into forebrain, midbrain and hindbrain. In conclusion, this model could provide a new platform for studying human-specific brain development.

Details

Authors
Organisations
External organisations
  • University of Copenhagen
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurosciences
  • Developmental Biology

Keywords

  • Human neural development, Microfluidics
Original languageEnglish
Title of host publicationMicroTAS 2017
Subtitle of host publicationSavannah, Georgia, USA
PublisherChemical and Biological Microsystems Society
Pages147-148
Number of pages2
ISBN (Electronic)9780692941836
Publication statusPublished - 2017
Publication categoryResearch
Peer-reviewedYes
Event21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 - Savannah, United States
Duration: 2017 Oct 222017 Oct 26

Publication series

NameMicroTAS
PublisherThe Chemical and Biological Microsystems Society (CBMS)
Volume2017
ISSN (Electronic)1556-5904

Conference

Conference21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
CountryUnited States
CitySavannah
Period2017/10/222017/10/26