Modulation of Calcium Overload and Calpain Activity

Research output: Contribution to journalArticle


title = "Modulation of Calcium Overload and Calpain Activity",
abstract = "Fluxes of calcium ions (Ca2+) in rod photoreceptors are major regulators of steady-state and light-evoked intracellular reactions to stimuli. The homeostasis of Ca2+ is regulated by channels and pumps localized at the plasma membrane and in intracellular organelles. Photoreceptor degeneration is frequently associated with Ca2+ homeostasis disruption and stimulation of Ca2+ activated proteases, such as calpains. These events trigger molecular pathways leading to cell death. In this chapter we discuss Ca2+ channels and pumps as well as calpains as potential targets of new therapies for retinal degeneration.",
author = "Fran{\cc}ois Paquet-Durand and Per Ekstr{\"o}m and Valeria Marigo",
year = "2019",
doi = "10.1039/9781788013666-00048",
language = "English",
volume = "2019-January",
pages = "48--60",
journal = "RSC Drug Discovery Series",
issn = "2041-3203",
publisher = "Royal Society of Chemistry",
number = "66",