Modulation of Calcium Overload and Calpain Activity

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Modulation of Calcium Overload and Calpain Activity. / Paquet-Durand, François; Ekström, Per; Marigo, Valeria.

In: RSC Drug Discovery Series, Vol. 2019-January, No. 66, 2019, p. 48-60.

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Paquet-Durand, François ; Ekström, Per ; Marigo, Valeria. / Modulation of Calcium Overload and Calpain Activity. In: RSC Drug Discovery Series. 2019 ; Vol. 2019-January, No. 66. pp. 48-60.

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TY - JOUR

T1 - Modulation of Calcium Overload and Calpain Activity

AU - Paquet-Durand, François

AU - Ekström, Per

AU - Marigo, Valeria

PY - 2019

Y1 - 2019

N2 - Fluxes of calcium ions (Ca2+) in rod photoreceptors are major regulators of steady-state and light-evoked intracellular reactions to stimuli. The homeostasis of Ca2+ is regulated by channels and pumps localized at the plasma membrane and in intracellular organelles. Photoreceptor degeneration is frequently associated with Ca2+ homeostasis disruption and stimulation of Ca2+ activated proteases, such as calpains. These events trigger molecular pathways leading to cell death. In this chapter we discuss Ca2+ channels and pumps as well as calpains as potential targets of new therapies for retinal degeneration.

AB - Fluxes of calcium ions (Ca2+) in rod photoreceptors are major regulators of steady-state and light-evoked intracellular reactions to stimuli. The homeostasis of Ca2+ is regulated by channels and pumps localized at the plasma membrane and in intracellular organelles. Photoreceptor degeneration is frequently associated with Ca2+ homeostasis disruption and stimulation of Ca2+ activated proteases, such as calpains. These events trigger molecular pathways leading to cell death. In this chapter we discuss Ca2+ channels and pumps as well as calpains as potential targets of new therapies for retinal degeneration.

U2 - 10.1039/9781788013666-00048

DO - 10.1039/9781788013666-00048

M3 - Article

VL - 2019-January

SP - 48

EP - 60

JO - RSC Drug Discovery Series

T2 - RSC Drug Discovery Series

JF - RSC Drug Discovery Series

SN - 2041-3203

IS - 66

ER -