Modulation of epileptogenesis: A paradigm for the integration of enzyme-based microelectrode arrays and optogenetics

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Bibtex

@article{ff099260acdb47f8a4b2accb47adadb0,
title = "Modulation of epileptogenesis: A paradigm for the integration of enzyme-based microelectrode arrays and optogenetics",
abstract = "BackgroundGenesis of acquired epilepsy includes transformations spanning genetic-to- network-level modifications, disrupting the regional excitatory/inhibitory balance. Methodology concurrently tracking changes at multiple levels is lacking. Here, viral vectors are used to differentially express two opsin proteins in neuronal populations within dentate gyrus (DG) of hippocampus. When activated, these opsins induced excitatory or inhibitory neural output that differentially affected neural networks and epileptogenesis. In vivo measures included behavioral observation coupled to real-time measures of regional glutamate flux using ceramic-based amperometric microelectrode arrays (MEAs).",
author = "Butler, {Corwin R.} and Boychuk, {Jeffery A.} and Francois Pomerleau and Ramona Alcala and Peter Huettl and Yi Ai and Johan Jakobsson and Whiteheart, {Sidney W.} and Gerhardt, {Greg A.} and Smith, {Bret N.} and Slevin, {John T}",
year = "2020",
month = "1",
day = "20",
doi = "https://doi.org/10.1016/j.eplepsyres.2019.106244",
language = "English",
volume = "159",
journal = "Epilepsy Research",
issn = "1872-6844",
publisher = "Elsevier",

}