Modulation of epileptogenesis: A paradigm for the integration of enzyme-based microelectrode arrays and optogenetics

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Modulation of epileptogenesis: A paradigm for the integration of enzyme-based microelectrode arrays and optogenetics. / Butler, Corwin R.; Boychuk, Jeffery A.; Pomerleau, Francois; Alcala, Ramona ; Huettl, Peter; Ai, Yi; Jakobsson, Johan; Whiteheart, Sidney W. ; Gerhardt, Greg A.; Smith, Bret N. ; Slevin, John T.

In: Epilepsy Research, Vol. 159, 106244, 20.01.2020.

Research output: Contribution to journalArticle

Harvard

Butler, CR, Boychuk, JA, Pomerleau, F, Alcala, R, Huettl, P, Ai, Y, Jakobsson, J, Whiteheart, SW, Gerhardt, GA, Smith, BN & Slevin, JT 2020, 'Modulation of epileptogenesis: A paradigm for the integration of enzyme-based microelectrode arrays and optogenetics', Epilepsy Research, vol. 159, 106244. https://doi.org/10.1016/j.eplepsyres.2019.106244

APA

Butler, C. R., Boychuk, J. A., Pomerleau, F., Alcala, R., Huettl, P., Ai, Y., ... Slevin, J. T. (2020). Modulation of epileptogenesis: A paradigm for the integration of enzyme-based microelectrode arrays and optogenetics. Epilepsy Research, 159, [106244]. https://doi.org/10.1016/j.eplepsyres.2019.106244

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Author

Butler, Corwin R. ; Boychuk, Jeffery A. ; Pomerleau, Francois ; Alcala, Ramona ; Huettl, Peter ; Ai, Yi ; Jakobsson, Johan ; Whiteheart, Sidney W. ; Gerhardt, Greg A. ; Smith, Bret N. ; Slevin, John T. / Modulation of epileptogenesis: A paradigm for the integration of enzyme-based microelectrode arrays and optogenetics. In: Epilepsy Research. 2020 ; Vol. 159.

RIS

TY - JOUR

T1 - Modulation of epileptogenesis: A paradigm for the integration of enzyme-based microelectrode arrays and optogenetics

AU - Butler, Corwin R.

AU - Boychuk, Jeffery A.

AU - Pomerleau, Francois

AU - Alcala, Ramona

AU - Huettl, Peter

AU - Ai, Yi

AU - Jakobsson, Johan

AU - Whiteheart, Sidney W.

AU - Gerhardt, Greg A.

AU - Smith, Bret N.

AU - Slevin, John T

PY - 2020/1/20

Y1 - 2020/1/20

N2 - BackgroundGenesis of acquired epilepsy includes transformations spanning genetic-to- network-level modifications, disrupting the regional excitatory/inhibitory balance. Methodology concurrently tracking changes at multiple levels is lacking. Here, viral vectors are used to differentially express two opsin proteins in neuronal populations within dentate gyrus (DG) of hippocampus. When activated, these opsins induced excitatory or inhibitory neural output that differentially affected neural networks and epileptogenesis. In vivo measures included behavioral observation coupled to real-time measures of regional glutamate flux using ceramic-based amperometric microelectrode arrays (MEAs).

AB - BackgroundGenesis of acquired epilepsy includes transformations spanning genetic-to- network-level modifications, disrupting the regional excitatory/inhibitory balance. Methodology concurrently tracking changes at multiple levels is lacking. Here, viral vectors are used to differentially express two opsin proteins in neuronal populations within dentate gyrus (DG) of hippocampus. When activated, these opsins induced excitatory or inhibitory neural output that differentially affected neural networks and epileptogenesis. In vivo measures included behavioral observation coupled to real-time measures of regional glutamate flux using ceramic-based amperometric microelectrode arrays (MEAs).

U2 - https://doi.org/10.1016/j.eplepsyres.2019.106244

DO - https://doi.org/10.1016/j.eplepsyres.2019.106244

M3 - Article

VL - 159

JO - Epilepsy Research

JF - Epilepsy Research

SN - 1872-6844

M1 - 106244

ER -