Molecular analysis of Philadelphia-positive childhood chronic myeloid leukemia.

Research output: Contribution to journalArticle

Abstract

The breakpoints in chromosome 22 were determined in five children with Philadelphia-positive chronic myeloid leukemia. All had rearrangements within the major breakpoint cluster region (M-bcr). Four patients had breakpoints in the 5' region of M-bcr (zones 1-3), whereas one had a rearrangement in the 3' region (zone 4). The patient with the 3' rearrangement was the only one to develop a lymphoid blast crisis; he also had a substantially longer survival (102 months) than the others (11-54 months).

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Subject classification (UKÄ) – MANDATORY

  • Cancer and Oncology
Original languageEnglish
Pages (from-to)723-725
JournalLeukemia
Volume6
Issue number7
Publication statusPublished - 1992
Publication categoryResearch
Peer-reviewedYes

Related research output

Thoas Fioretos, 1996, Department of Clinical Genetics, Lund University. 60 p.

Research output: ThesisDoctoral Thesis (compilation)

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