Molecular imaging with endogenous substances

Research output: Contribution to journalArticle

Abstract

Dynamic nuclear polarization has enabled hyperpolarization of nuclei such as C-13 and N-15 in endogenous substances. The resulting high nuclear polarization makes it possible to perform subsecond C-13 MRI. By using the dynamic nuclear polarization hyperpolarization technique, 10% polarization was obtained in an aqueous solution of 100 mM C-13-labeled urea, ready for injection. The in vivo T, relaxation time of C-13 in the urea solution was determined to 20 +/- 2 s. Due to the long relaxation time, it is possible to use the hyperpolarized substance for medical imaging. A series of high-resolution (approximate to1-mm) magnetic resonance images were acquired, each with a scan time of 240 ms, 0-5 s after an i.v. injection of the hyperpolarized aqueous [C-13]urea solution in a rat. The results show that it is possible to perform C-13 angiography with a signal-to-noise ratio of approximate to275 in approximate to0.25 s. Perfusion studies with endogenous substances may allow higher spatial and/or temporal resolution than is possible with current proton imaging techniques.

Details

Authors
  • Klaes Golman
  • JH Ardenaer-Larsen
  • JS Petersson
  • Sven Månsson
  • I Leunbach
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Radiology, Nuclear Medicine and Medical Imaging
Original languageEnglish
Pages (from-to)10435-10439
JournalProceedings of the National Academy of Sciences
Volume100
Issue number18
Publication statusPublished - 2003
Publication categoryResearch
Peer-reviewedYes