Molecular profiling of breast cancer: transcriptomic studies and beyond

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Abstract

Utilisation of 'omics' technologies, in particular gene expression profiling, has increased dramatically in recent years. In basic research, high-throughput profiling applications are increasingly used and may now even be considered standard research tools. In the clinic, there is a need for better and more accurate diagnosis, prognosis and treatment response indicators. As such, clinicians have looked to omics technologies for potential biomarkers. These prediction profiling studies have in turn attracted the attention of basic researchers eager to uncover biological mechanisms underlying clinically useful signatures. Here we highlight some of the seminal work establishing the arrival of the omics, in particular transcriptomics, in breast cancer research and discuss a sample of the most current applications. We also discuss the challenges of data analysis and integrated data analysis with emphasis on utilising the current publicly available gene expression datasets.

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  • Cancer and Oncology
Original languageEnglish
Pages (from-to)3185-3200
JournalCellular and Molecular Life Sciences
Volume64
Issue number24
Publication statusPublished - 2007
Publication categoryResearch
Peer-reviewedYes