Monoclonal gammopathy of undetermined significance (MGUS) and smoldering (asymptomatic) multiple myeloma: IMWG consensus perspectives risk factors for progression and guidelines for monitoring and management

Research output: Contribution to journalReview article

Abstract

Monoclonal gammopathy of undetermined significance (MGUS) was identified in 3.2% of 21 463 residents of Olmsted County, Minnesota, 50 years of age or older. The risk of progression to multiple myeloma, Waldenstrom's macroglobulinemia, AL amyloidosis or a lymphoproliferative disorder is approximately 1% per year. Low-risk MGUS is characterized by having an M protein < 15 g/l, IgG type and a normal free light chain (FLC) ratio. Patients should be followed with serum protein electrophoresis at six months and, if stable, can be followed every 2-3 years or when symptoms suggestive of a plasma cell malignancy arise. Patients with intermediate and high-risk MGUS should be followed in 6 months and then annually for life. The risk of smoldering (asymptomatic) multiple myeloma (SMM) progressing to multiple myeloma or a related disorder is 10% per year for the first 5 years, 3% per year for the next 5 years and 1-2% per year for the next 10 years. Testing should be done 2-3 months after the initial recognition of SMM. If the results are stable, the patient should be followed every 4-6 months for 1 year and, if stable, every 6-12 months. Leukemia (2010) 24, 1121-1127; doi:10.1038/leu.2010.60; published online 22 April 2010

Details

Authors
  • R. A. Kyle
  • B. G. M. Durie
  • S. V. Rajkumar
  • O. Landgren
  • J. Blade
  • G. Merlini
  • N. Kroeger
  • H. Einsele
  • D. H. Vesole
  • M. Dimopoulos
  • J. San Miguel
  • H. Avet-Loiseau
  • R. Hajek
  • W. M. Chen
  • K. C. Anderson
  • H. Ludwig
  • P. Sonneveld
  • S. Pavlovsky
  • A. Palumbo
  • P. G. Richardson
  • B. Barlogie
  • P. Greipp
  • R. Vescio
  • J. Westin
  • M. Boccadoro
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cancer and Oncology

Keywords

  • MGUS, International Myeloma Working Group, myeloma, monoclonal gammopathy of undetermined significance, smoldering multiple
Original languageEnglish
Pages (from-to)1121-1127
JournalLeukemia
Volume24
Issue number6
Publication statusPublished - 2010
Publication categoryResearch
Peer-reviewedYes