Morphological detection of neurogenic muscle disorders: how can statistical methods aid diagnosis?

Research output: Contribution to journalArticle

Abstract

The light microscopical observation of groups of histochemically similar muscle fibres, referred to as fibre-type grouping, is commonly considered to be evidence of a denervation and reinnervation process affecting the spinal motor neurons or the peripheral nerves. It can be difficult to assess whether such groups have occurred by chance or are due to a slowly progressive pathological process in an early stage of development. Consequently, there is a need for one or more objective methods for assessing the fibre-type arrangement in healthy and diseased human muscles. The purposes here are to review the methods for the detection of fibre-type grouping that have been published in the last two decades, to describe some unsolved problems, and to indicate some likely lines of development.

Details

Authors
External organisations
  • External Organization - Unknown
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurosciences

Keywords

  • Nerve degeneration, Muscular atrophy, Muscle denervation, Histocytochemistry, Aging
Original languageEnglish
Pages (from-to)109-115
JournalActa Neuropathologica
Volume75
Issue number2
Publication statusPublished - 1987
Publication categoryResearch
Peer-reviewedYes
Externally publishedYes