Mortality and Inherited Thrombophilia: results from the European Prospective Cohort on Thrombophilia (EPCOT).

Research output: Contribution to journalArticle


Background: Data on the survival of individuals with hereditary thrombophilia are rare and only come from retrospective studies. Objective: We aimed to assess mortality in individuals with known thrombophilia with and without a history of thrombosis in comparison to a control group. Patients/Methods: The European Prospective Cohort on Thrombophilia (EPCOT) study is a prospective multi-centre observational study performed to assess the risk of thrombosis in persons with inherited thrombophilia. In an extension of this study the vital status was assessed in 1,240 individuals with thrombophilia (mean age 40.9 years, 59% women, 196 with antithrombin-, 341 with protein C-, 276 with protein S-deficiency, 330 with factor V Leiden and 97 with combined defects, 62% with a VT history) and 875 controls (mean age 42.5 years, 48% women, 7% with a VT history). Results: Seventy-two individuals with thrombophilia and 45 controls died during follow-up. The risk of death, adjusted for sex, thrombosis-history and centre, was not associated with thrombophilia (hazard ratio (HR) thrombophilia individuals versus controls: 1.09, 95% confidence interval (CI) 0.66-1.78). When individuals with thrombophilia were evaluated separately, a history of thrombosis was not associated with mortality: the risk of death after adjustment for sex, anticoagulation and center was HR 0.79 (95% CI 0.41-1.54). Conclusions: No increased risk of death in individuals with thrombophilia, not even in those with a history of thrombosis, was observed.


  • I Pabinger
  • C Y Vossen
  • J Lang
  • J Conard
  • M C García-Dabrio
  • W Miesbach
  • C Legnani
  • Peter Svensson
  • A Kaider
  • F R Rosendaal
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cardiac and Cardiovascular Systems


  • deep vein thrombosis mortality, pulmonary embolism, survival, thrombophilia, venous thromboembolism
Original languageEnglish
Pages (from-to)217-222
JournalJournal of Thrombosis and Haemostasis
Issue number2
Publication statusPublished - 2012
Publication categoryResearch