Mortality risk comparing walking pace to handgrip strength and a healthy lifestyle: A UK Biobank study

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Mortality risk comparing walking pace to handgrip strength and a healthy lifestyle : A UK Biobank study. / Zaccardi, Francesco; Franks, Paul W.; Dudbridge, Frank; Davies, Melanie J.; Khunti, Kamlesh; Yates, Thomas.

In: European Journal of Preventive Cardiology, 12.11.2019.

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Zaccardi, Francesco ; Franks, Paul W. ; Dudbridge, Frank ; Davies, Melanie J. ; Khunti, Kamlesh ; Yates, Thomas. / Mortality risk comparing walking pace to handgrip strength and a healthy lifestyle : A UK Biobank study. In: European Journal of Preventive Cardiology. 2019.

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TY - JOUR

T1 - Mortality risk comparing walking pace to handgrip strength and a healthy lifestyle

T2 - A UK Biobank study

AU - Zaccardi, Francesco

AU - Franks, Paul W.

AU - Dudbridge, Frank

AU - Davies, Melanie J.

AU - Khunti, Kamlesh

AU - Yates, Thomas

PY - 2019/11/12

Y1 - 2019/11/12

N2 - Aims: Brisk walking and a greater muscle strength have been associated with a longer life; whether these associations are influenced by other lifestyle behaviours, however, is less well known. Methods: Information on usual walking pace (self-defined as slow, steady/average, or brisk), dynamometer-assessed handgrip strength, lifestyle behaviours (physical activity, TV viewing, diet, alcohol intake, sleep and smoking) and body mass index was collected at baseline in 450,888 UK Biobank study participants. We estimated 10-year standardised survival for individual and combined lifestyle behaviours and body mass index across levels of walking pace and handgrip strength. Results: Over a median follow-up of 7.0 years, 3808 (1.6%) deaths in women and 6783 (3.2%) in men occurred. Brisk walkers had a survival advantage over slow walkers, irrespective of the degree of engagement in other lifestyle behaviours, except for smoking. Estimated 10-year survival was higher in brisk walkers who otherwise engaged in an unhealthy lifestyle compared to slow walkers who engaged in an otherwise healthy lifestyle: 97.1% (95% confidence interval: 96.9–97.3) vs 95.0% (94.6–95.4) in women; 94.8% (94.7–95.0) vs 93.7% (93.3–94.2) in men. Body mass index modified the association between walking pace and survival in men, with the largest survival benefits of brisk walking observed in underweight participants. Compared to walking pace, for handgrip strength there was more overlap in 10-year survival across lifestyle behaviours. Conclusion: Except for smoking, brisk walkers with an otherwise unhealthy lifestyle have a lower mortality risk than slow walkers with an otherwise healthy lifestyle.

AB - Aims: Brisk walking and a greater muscle strength have been associated with a longer life; whether these associations are influenced by other lifestyle behaviours, however, is less well known. Methods: Information on usual walking pace (self-defined as slow, steady/average, or brisk), dynamometer-assessed handgrip strength, lifestyle behaviours (physical activity, TV viewing, diet, alcohol intake, sleep and smoking) and body mass index was collected at baseline in 450,888 UK Biobank study participants. We estimated 10-year standardised survival for individual and combined lifestyle behaviours and body mass index across levels of walking pace and handgrip strength. Results: Over a median follow-up of 7.0 years, 3808 (1.6%) deaths in women and 6783 (3.2%) in men occurred. Brisk walkers had a survival advantage over slow walkers, irrespective of the degree of engagement in other lifestyle behaviours, except for smoking. Estimated 10-year survival was higher in brisk walkers who otherwise engaged in an unhealthy lifestyle compared to slow walkers who engaged in an otherwise healthy lifestyle: 97.1% (95% confidence interval: 96.9–97.3) vs 95.0% (94.6–95.4) in women; 94.8% (94.7–95.0) vs 93.7% (93.3–94.2) in men. Body mass index modified the association between walking pace and survival in men, with the largest survival benefits of brisk walking observed in underweight participants. Compared to walking pace, for handgrip strength there was more overlap in 10-year survival across lifestyle behaviours. Conclusion: Except for smoking, brisk walkers with an otherwise unhealthy lifestyle have a lower mortality risk than slow walkers with an otherwise healthy lifestyle.

KW - absolute risk

KW - grip strength

KW - lifestyle

KW - mortality

KW - smoking

KW - Walking pace

UR - http://www.scopus.com/inward/record.url?scp=85075118742&partnerID=8YFLogxK

U2 - 10.1177/2047487319885041

DO - 10.1177/2047487319885041

M3 - Article

C2 - 31711304

AN - SCOPUS:85075118742

JO - European Journal of Preventive Cardiology

JF - European Journal of Preventive Cardiology

SN - 2047-4881

ER -