Mortality risks associated with sibling heart failure

Research output: Contribution to journalArticle


Background The mortality in individuals with a family history of heart failure (HF) has not been determined. This nationwide sib-pair study aimed to determine mortality in individuals with a sibling affected with HF. Methods Sib-pairs were linked using the Swedish Multi-Generation Register, the Hospital Discharge Register and the Cause of Death Register for the period 1987–2012. Families with cardiomyopathy or congenital heart disease were excluded. Mortality hazard ratios (HRs) were calculated for siblings of individuals who had been diagnosed with HF compared with siblings of individuals unaffected by HF as the reference group. Similar analyses were made for spouses. HRs were determined for overall mortality, cardiovascular mortality, and death of unknown cause. Results Among siblings, the adjusted HR for overall mortality was 1.21 (95% CI 1.18–1.25). This risk remained (HR = 1.19, 95% CI 1.15–1.23) also among subjects without HF themselves. The adjusted HRs for cardiovascular mortality and death of unknown cause were 1.39 (95% CI 1.32–1.45) and 1.58 (95% CI 1.29–1.95), respectively. The mortality risk associations with spousal HF were all minimal, with an overall mortality HR of 1.02 (1.01–1.02). Early sibling age of onset of HF 


External organisations
  • Skåne University Hospital
  • Center for Primary Health Care Research
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cardiac and Cardiovascular Systems
  • Public Health, Global Health, Social Medicine and Epidemiology
  • Medical Genetics


  • Heart failure, Family history, Mortality, Genetics, Epidemiology
Original languageEnglish
Pages (from-to)114-118
Number of pages5
JournalInternational Journal of Cardiology
Early online date2019 Oct 12
Publication statusPublished - 2020 May 15
Publication categoryResearch

Related research output

Magnus Lindgren, 2020, Lund: Lund University, Faculty of Medicine. 84 p.

Research output: ThesisDoctoral Thesis (compilation)

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