Motilin concentrations in relation to gastro intestinal dysmotility in diabetes mellitus.

Research output: Contribution to journalArticle

Abstract

AIM: Dysmotility in the upper gastro intestinal (GI) tract are common problems in diabetics. Many peptides are involved in the regulation of the motility. The aim of this study was to examine whether plasma levels of motilin were related to dysfunction in the oesophagus and stomach in a well-defined diabetic patient group. METHODS: Nineteen patients with symptoms from the GI tract who had been examined with oesophageal manometry, gastric emptying scintigraphy and deep-breathing test were included. They received a fat-rich meal, after which blood samples were collected and analysed for motilin concentrations. RESULTS: Symptoms of abdominal fullness and gastro oesophageal reflux significantly associated with delayed gastric emptying, whereas no symptom correlated to oesophageal dysmotility. Plasma levels of motilin were increased after the fat-rich meal (p=0.000), with no difference between the groups. Abnormal manometry was characterized by aperistalsis and/or simultaneous contractions. The percentage of simultaneous contractions correlated to basic and peak motilin values (r(s)=0.898, p=0.006 and r(s)=0.842, p=0.017, respectively). Gastric emptying did not influence motilin concentrations. CONCLUSION: Plasma motilin concentrations vary with abnormalities of oesophageal motility in diabetics, but not with abnormalities of gastric emptying.

Details

Authors
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Family Medicine
Original languageEnglish
Pages (from-to)654-659
JournalEuropean Journal of Internal Medicine
Volume20
Issue number6
Publication statusPublished - 2009
Publication categoryResearch
Peer-reviewedYes

Related research output

Hillevi Pendleton, 2013, Disease of the Paranasal Sinus, Cancer and HRQL, Lund University. 140 p.

Research output: ThesisDoctoral Thesis (compilation)

View all (1)