Mouse monoclonal antibodies with anti-A, anti-B and anti-A,B specificities; some superior to human polyclonal ABO reagents

Research output: Contribution to journalArticle

Abstract

A series of fusions using mouse myeloma cells and spleen cells from mice immunized with blood group substances or human red cells was performed with the aim of obtaining ABO antibodies suitable for routine blood grouping. Seven strongly agglutinating antibodies against antigens in the ABO system were obtained from 18 fusions. These antibodies were tested extensively in manual and automated routines, and six of them were found to be as good as or better than commercial polyclonal test sera of human origin.

Details

Authors
  • L Messeter
  • T Brodin
  • Alan Chester
  • B Low
  • A Lundblad
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Hematology
Original languageEnglish
Pages (from-to)185-194
JournalVox Sanguinis
Volume46
Issue number4
Publication statusPublished - 1984
Publication categoryResearch
Peer-reviewedYes