Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

Research output: Contribution to journalArticle

Abstract

The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene–smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings. © 2019, This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply.

Details

Authors
Organisations
External organisations
  • National Human Genome Research Institute
  • Framingham Heart Study
  • Boston University
  • National Heart Lung and Blood Institute
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Medical Genetics
Original languageEnglish
Pages (from-to)636-648
Number of pages13
JournalNature Genetics
Volume51
Issue number4
Publication statusPublished - 2019
Publication categoryResearch
Peer-reviewedYes

Bibliographic note

Export Date: 26 April 2019