Multiscale Modeling of Insulin Secretion

Research output: Contribution to journalArticle

Abstract

Insulin secretion from pancreatic beta cells is a fundamental physiological process, and its impairment plays a pivotal role in the development of diabetes. Mathematical modeling of insulin secretion has a long history, both on the level of the entire body and on the cellular and subcellular scale. However, little direct communication between these disparate scales has been included in mathematical models so far. Recently, we have proposed a minimal model for the incretin effect by which the gut hormone glucagon-like peptide 1 (GLP-1) enhances insulin secretion. To understand how this model couples to cellular events, we use a previously published mechanistic model of insulin secretion, and show mathematically that induction of glucose competence in beta cells by GLP-1 can underlie derivative control by GLP-1.

Details

Authors
  • Morten Gram Pedersen
  • Chiara Dalla Man
  • Claudio Cobelli
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Medical Engineering

Keywords

  • Derivative control, glucagon-like peptide 1 (GLP-1), incretins, insulin, granules, threshold distribution
Original languageEnglish
Pages (from-to)3020-3023
JournalIEEE Transactions on Biomedical Engineering
Volume58
Issue number10
Publication statusPublished - 2011
Publication categoryResearch
Peer-reviewedYes