Multispectral guided fluorescence diffuse optical tomography using upconverting nanoparticles

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Abstract

We report on improved image detectability for fluorescence diffuse optical tomography using upconverting nanoparticles doped with rare-earth elements. Core-shell NaYF4 : Yb3+/Er3+ @ NaYF4 upconverting nanoparticles were synthesized through a stoichiometric method. The Yb3+/Er3+ sensitizer-activator pair yielded two anti-Stokes shifted fluorescence emission bands at 540 nm and 660 nm, here used to a priori estimate the fluorescence source depth with sub-millimeter precision. A spatially varying regularization incorporated the a priori fluorescence source depth estimation into the tomography reconstruction scheme. Tissue phantom experiments showed both an improved resolution and contrast in the reconstructed images as compared to not using any a priori information. (C) 2014 AIP Publishing LLC.

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  • Atom and Molecular Physics and Optics
Original languageEnglish
Article number073703
JournalApplied Physics Letters
Volume104
Issue number7
Publication statusPublished - 2014
Publication categoryResearch
Peer-reviewedYes