Multistep solution-phase parallel synthesis of spiperone analogues
Research output: Contribution to journal › Article
Abstract
A flexible, multistep parallel synthesis of spiperone analogues is described. A library of 4-substituted piperidines, assembled utilizing reductive amination and acylation protocols, was alkylated either homogeneously or heterogeneously, exploiting a product release only concept, to afford an oxa-series of spiperone analogues. Screening of the products at 5-HT2 and D2 receptors revealed 5-HT(2A) antagonists with improved selectivity compared to spiperone and AMI-193. (C) 2000 Published by Elsevier Science Ltd.
Details
| Authors | |
|---|---|
| External organisations |
|
| Research areas and keywords | Subject classification (UKÄ) – MANDATORY
|
| Original language | English |
|---|---|
| Pages (from-to) | 2435-2439 |
| Journal | Bioorganic and Medicinal Chemistry Letters |
| Volume | 10 |
| Issue number | 21 |
| Publication status | Published - 2000 Nov 6 |
| Publication category | Research |
| Peer-reviewed | Yes |
| Externally published | Yes |
