Myeloid and lymphoid contribution to non-haematopoietic lineages through irradiation-induced heterotypic cell fusion.

Research output: Contribution to journalArticle

Abstract

Recent studies have suggested that regeneration of non-haematopoietic cell lineages can occur through heterotypic cell fusion with haematopoietic cells of the myeloid lineage. Here we show that lymphocytes also form heterotypic-fusion hybrids with cardiomyocytes, skeletal muscle, hepatocytes and Purkinje neurons. However, through lineage fate-mapping we demonstrate that such in vivo fusion of lymphoid and myeloid blood cells does not occur to an appreciable extent in steady-state adult tissues or during normal development. Rather, fusion of blood cells with different non-haematopoietic cell types is induced by organ-specific injuries or whole-body irradiation, which has been used in previous studies to condition recipients of bone marrow transplants. Our findings demonstrate that blood cells of the lymphoid and myeloid lineages contribute to various non-haematopoietic tissues by forming rare fusion hybrids, but almost exclusively in response to injuries or inflammation.

Details

Authors
  • Jens Nygren
  • Karina Liuba
  • Martin Breitbach
  • Simon Stott
  • Lina Thorén
  • Wilhelm Roell
  • Caroline Geisen
  • Philipp Sasse
  • Deniz Kirik
  • Anders Björklund
  • Claus Nerlov
  • Bernd K Fleischmann
  • Stefan Jovinge
  • Sten Eirik W Jacobsen
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cell and Molecular Biology
Original languageEnglish
Pages (from-to)584-592
JournalNature Cell Biology
Volume10
Issue number5
Publication statusPublished - 2008
Publication categoryResearch
Peer-reviewedYes

Related research output

Liuba, K., 2009, Department of Obstetrics and Gynecology, Lund University. 71 p.

Research output: ThesisDoctoral Thesis (compilation)

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