Myeloid-related protein 14 promote inflammation and injury in meningitis.

Research output: Contribution to journalArticle

Abstract

Neutrophilic inflammation often persists over days despite efficient antibiotic treatment and contributes to brain damage in bacterial meningitis. We proposed here that MRP14, an abundant cytosolic protein in myeloid cells, acts as an endogenous danger signal, driving inflammation and aggravating tissue injury.

Details

Authors
  • Christina Wache
  • Matthias Klein
  • Christian Ostergaard
  • Barbara Angele
  • Hans Häcker
  • Hans-Walter Pfister
  • Monika Pruenster
  • Markus Sperandio
  • Tomas Leanderson
  • Johannes Roth
  • Thomas Vogl
  • Uwe Koedel
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Infectious Medicine
Original languageEnglish
Pages (from-to)247-257
JournalJournal of Infectious Diseases
Volume212
Issue number2
Publication statusPublished - 2015
Publication categoryResearch
Peer-reviewedYes