MyelomA Genetics International Consortium

Research output: Contribution to journalReview article

Abstract

While the etiology of multiple myeloma (MM) is largely unknown, evidence for an inherited genetic susceptibility is provided by the two-fold increased risk of the disease seen in first-degree relatives of cases of MM. It is likely that part of this heritable risk is a consequence of the co-inheritance of low-risk genetic variants. The accumulated experience to date in identifying risk variants for other tumors has highlighted difficulties in conducting statistically and methodologically rigorous studies. The MyelomA Genetics International Consortium (MAGIC) includes 16 research groups in Europe, Asia, Australasia, the Middle East and the Americas engaged in studying the genetics of MM. The first goal of MAGIC is to identify and characterize common genetic variants for MM through association-based analyses. Here, we review the rationale for identifying genetic risk variants for MM and our proposed strategy for establishing MAGIC.

Details

Authors
  • Gareth Morgan
  • Hans Erik Johnsen
  • Hartmut Goldschmidt
  • Antonio Palumbo
  • Michele Cavo
  • Pieter Sonneveld
  • Jesus San Miguel
  • Char Sang Chim
  • Paul Browne
  • Hermann Einsele
  • Anders Waage
  • Ingemar Turesson
  • Andrew Spencer
  • Roman Hajek
  • Heinz Ludwig
  • Kari Hemminki
  • Richard Houlston
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cancer and Oncology

Keywords

  • Multiple myeloma, genetics, consortium, etiology
Original languageEnglish
Pages (from-to)796-800
JournalLeukemia & Lymphoma
Volume53
Issue number5
Publication statusPublished - 2012
Publication categoryResearch
Peer-reviewedYes

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200)