Nanoassemblies from vitamin C derivatives

Research output: Chapter in Book/Report/Conference proceedingPaper in conference proceeding


Vitamin C is one of the most effective natural antioxidants. However, due to its poor solubility in non-aqueous environments, its use is restricted to water-based systems. In order to extend its advantages to lipophilic media, vitamin C must be converted into amphiphilic derivatives. Two new vitamin C-based surfactants were synthesized: a bolaform derivative (1,12-diascorbyl dodecanedioate, BOLA12), and a double chain product (2-octyl-dodecanoyl6-0- ascorbic acid, 8ASC10). Once dispersed in water above 0.5% w/w, BOLA12 forms hollow nanotubes that transform into clear micellar solutions on heating. 8ASC10 is poorly soluble in aqueous media, but it dissolves easily in cyclohexane where it forms true organogels. Cryo-TEM, XRD, SAXS, conductivity, viscosity and DSC experiments were performed in order to study the aggregation properties and morphology of these nanoassemblies.


  • P. Lo Nostro
  • M. Ambrosi
  • E. Fratini
  • F. Ridi
  • E. Carretti
  • M. Lagi
  • V. Alfredsson
  • B. W. Ninham
  • P. Baglioni
External organisations
  • University of Florence
  • Australian National University
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Physical Chemistry


  • Antioxidant, Ascorbic acid, Nanoparticles, Organogel, Vitamin C
Original languageEnglish
Title of host publication2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007, Technical Proceedings
Number of pages4
Publication statusPublished - 2007 Aug 23
Publication categoryResearch
Event2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007 - Santa Clara, CA, United States
Duration: 2007 May 202007 May 24


Conference2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007
CountryUnited States
CitySanta Clara, CA