Nano-scale Infrared Imaging of β-sheet Structures in Synaptic Junctions of Primary Neurons Isolated from Transgenic Mice

Research output: Chapter in Book/Report/Conference proceedingPaper in conference proceeding

Abstract

Aβ is a class of aggregation-prone proteins, which may misfold into stable, β-sheet rich fibrils. Aβ is linked to the development of synaptic pathology in Alzheimer's disease (AD). However, a main question in the AD field is how Aβ contributes to AD neuropathology? Up to now there is little evidence for protein structural changes in diseased neuron. Our aim is to study the distribution of β-sheet structures in AD transgenic neurons in order to uncover sub-cellular mechanism(s) by which amyloid β-sheet structures are involved in AD pathology.

Details

Authors
Organisations
External organisations
  • University of Paris-Sud
  • Brookhaven National Laboratory
  • Brazilian Synchroton Light Laboratory
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurosciences
  • Medical Image Processing
Original languageEnglish
Title of host publication2018 43rd International Conference on Infrared Millimeter and Terahertz Waves, IRMMW-THz 2018
PublisherIEEE Computer Society
Volume2018-September
ISBN (Electronic)9781538638095
Publication statusPublished - 2018 Oct 29
Publication categoryResearch
Peer-reviewedYes
Event43rd International Conference on Infrared Millimeter and Terahertz Waves, IRMMW-THz 2018 - Nagoya, Japan
Duration: 2018 Sep 92018 Sep 14

Conference

Conference43rd International Conference on Infrared Millimeter and Terahertz Waves, IRMMW-THz 2018
CountryJapan
CityNagoya
Period2018/09/092018/09/14