Nanostructured Lipid-Based Films for Substrate-Mediated Applications in Biotechnology

Research output: Contribution to journalArticle

Abstract

Amphiphilic in nature, lipids spontaneously self-assemble into a range of nanostructures in the presence of water. Among lipid self-assembled structures, liposomes and supported lipid bilayers have long held scientific interest for their main applications in drug delivery and plasma membrane models, respectively. In contrast, lipid-based multilayered membranes on solid supports only recently begin drawing scientists' attention. Current studies show that the stacking of multiple bilayers on a solid support yields cooperative structural and dynamic behavior that enables new functionalities. Lipid films provide compartmentalization, templating, and enhanced release of molecules of interest. Importantly, supported lipid phases exhibit long-range periodic nanoscale order and orientation that is tunable in response to a changing environment. Herein, the current understanding of lipid-based film research is summarized focusing on how unique structural characteristics enable the emergence of new applications including label-free biosensors, macroscale drug delivery, and substrate-mediated gene delivery. The authors' recent contributions focusing on the structural characterization of lipid-based films using small-angle X-ray scattering and atomic force microscopy are highlighted. In addition, new photothermally induced resonance and solid-state nuclear magnetic resonance data are described, providing insights into drug partition in lipid-based films as well as structure and dynamics at the molecular scale.

Details

Authors
Organisations
External organisations
  • University of Illinois at Urbana-Champaign
  • University of Maryland
  • National Institute of Standards and Technology
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Materials Chemistry

Keywords

  • Lipid films, Lipid-polymer hybrids, Solid-state NMR, Substrate-mediated delivery, Supported membranes
Original languageEnglish
Article number1704356
JournalAdvanced Functional Materials
Volume28
Issue number9
Early online date2018 Jan 10
Publication statusPublished - 2018
Publication categoryResearch
Peer-reviewedYes