Natural corollaries and recovery after acute ACL injury: The NACOX cohort study protocol

Research output: Contribution to journalArticle

Abstract

Introduction Anterior cruciate ligament (ACL) injury can result in joint instability, decreased functional performance, reduced physical activity and quality of life and an increased risk for post-traumatic osteoarthritis. Despite the development of new treatment techniques and extensive research, the complex and multifaceted nature of ACL injury and its consequences are yet to be fully understood. The overall aim of the NACOX study is to evaluate the natural corollaries and recovery after an ACL injury. Methods and analysis The NACOX study is a multicentre prospective prognostic cohort study of patients with acute ACL injury. At seven sites in Sweden, we will include patients aged 15-40 years, within 6 weeks after primary ACL injury. Patients will complete questionnaires at multiple occasions over the 3 years following injury or the 3 years following ACL reconstruction (for participants who have surgical treatment). In addition, a subgroup of 130 patients will be followed with clinical examinations, several imaging modalities and biological samples. Data analyses will be specific to each aim. Ethics and dissemination This study has been approved by the regional Ethical committee in Linköping, Sweden (Dnr 2016/44-31 and 2017/221-32). We plan to present the results at national and international conferences and in peer-reviewed scientific journals. Participants will receive a short summary of the results following completion of the study. Trial registration number NCT02931084.

Details

Authors
  • Joanna Kvist
  • Håkan Gauffin
  • Hanna Tigerstrand Grevnerts
  • Clare Ardern
  • Martin Hägglund
  • Anders Stålman
  • Richard Frobell
Organisations
External organisations
  • Linköping University
  • Karolinska Institutet
  • La Trobe University
  • Sophiahemmet Hospital
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Physiotherapy

Keywords

  • knee, magnetic resonance imaging, musculoskeletal disorders, sports medicine
Original languageEnglish
Article numbere020543
JournalBMJ Open
Volume8
Issue number6
Publication statusPublished - 2018 Jun 1
Publication categoryResearch
Peer-reviewedYes