Natural Pseudoguaianolides Prepared from Damsin

Research output: Contribution to journalArticle

Abstract

Damsin (1) is a pseudoguaianolide sesquiterpene possessing potent biological activities, reported as a metabolite of several medicinal plants belonging to the genus Ambrosia together with related compounds. Starting from 1, which can be isolated in good amounts from Ambrosia arborescens, the five natural pseudoguaianolides ambrosin (2), isodamsin (3), 3 alpha-hydroxydamsin (4), 3 alpha-acetoxydamsin (5), and 11 beta,13-dihydrodamsin (8) were prepared by regio- and stereo-selective synthetic modifications.

Details

Authors
Organisations
External organisations
  • Higher University of San Andrés
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Organic Chemistry

Keywords

  • sesquiterpene lactones, pseudoguaianolides, semi-synthesis, ambrosanolides, derivatization, damsin
Original languageEnglish
Pages (from-to)675-680
JournalChemistry of Natural Compounds
Volume51
Issue number4
Publication statusPublished - 2015
Publication categoryResearch
Peer-reviewedYes