Neonatal pre-ganglionic sympathectomy affects morphometrically defined architecture in rat cerebral arteries

Research output: Contribution to journalArticle

Abstract

In order to clarify further the nature of the long-term influence on the cerebral vasculature by the sympathetic nerves, a bilateral cervical pre-ganglionic denervation was performed in 1-week-old rats. Four weeks later, morphometric determinations of the vascular dimensions revealed diminished media cross-sectional areas and luminal radii in the middle cerebral and posterior cerebral arteries, whereas these parameters were unaffected in the basilar artery. In the latter artery, however, a 40% increase in the cross-sectional area of the internal elastic membrane was found. No re-innervation of the denervated ganglia occurred during the course of the experiment. The results suggest that the long-term effect exerted by the sympathetic nerves is associated with the nerve activity, rather than being a true trophic influence.

Details

Authors
  • J Kåhrström
  • Jan Erik Hardebo
  • C Nordborg
  • Christer Owman
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Pharmacology and Toxicology
  • Neurology

Keywords

  • chronic sympathectomy, morphometry, pial arteries, sympathetic nerves, trophic effect
Original languageEnglish
Pages (from-to)225-231
JournalActa Physiologica Scandinavica
Volume157
Issue number2
Publication statusPublished - 1996
Publication categoryResearch
Peer-reviewedYes