Neurobiology of Postischemic Recuperation in the Aged Mammalian Brain

Research output: Chapter in Book/Report/Conference proceedingBook chapter

Abstract

Old age is associated with an enhanced susceptibility to stroke and poor recovery from brain injury, but the cellular processes underlying these phenomena are not well understood. Potential mechanism underlying functional recovery after brain ischemia in aged subjects include neuroinflammation, changes in brain plasticity-promoting factors, unregulated expression of neurotoxic factors, or differences in the generation of scar tissue that impedes the formation of new axons and blood vessels in the infarcted region. Studies suggest that behaviorally, aged rats were more severely impaired by ischemia than were young rats and showed diminished functional recovery. Both in old and young rats, the early intense proliferative activity following stroke leads to a precipitous formation of growthinhibiting scar tissue, a phenomenon amplified by the persistent expression of neurotoxic factors. Recent evidence shows that the human brain can respond to stroke with increased progenitor proliferation in aged patients, opening the possibilities of utilizing this intrinsic attempt for neuroregeneration of the human brain as a potential therapy for ischemic stroke.

Details

Authors
Organisations
External organisations
  • University of Greifswald
  • Carol Davila University of Medicine and Pharmacy
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurosciences

Keywords

  • Brain, Ischemic stroke, Neurobiology, Neuroinflammation, Neuroregeneration, Neurotoxic factors, Scar tissue
Original languageEnglish
Title of host publicationNeurovascular Medicine
Subtitle of host publicationPursuing Cellular Longevity for Healthy Aging
PublisherOxford University Press
Chapter17
ISBN (Electronic)9780199864874
ISBN (Print)9780195326697
Publication statusPublished - 2010 Jan
Publication categoryResearch
Peer-reviewedYes